calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate
Calcium folinatc
CAS: 1492-18-8
Molecular Formula: C20H25CaN7O7
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Names and Identifiers
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Physico-chemical Properties
| Molecular Formula | C20H25CaN7O7 |
| Molar Mass | 515.54 |
| Melting Point | >300°C |
| Solubility | Sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). |
| Appearance | Yellow crystalline powder |
| Color | Pale Yellow to Light Yellow |
| BRN | 5723924 |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Hygroscopic |
| MDL | MFCD00006704 |
| Use | It is mainly used as an antidote for folic acid antagonists such as methotrexate, pyrimethamine or trimethoprim. 2. For the Prevention of methotrexate overdose or high-dose treatment caused by serious toxic effects. 3. Megaloblastic anemia caused by folic acid deficiency. 4. When combined with fluorouracil, it is used for the treatment of advanced colon cancer and rectal cancer. |
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | MA0600500 |
| FLUKA BRAND F CODES | 3-8-10-23 |
| HS Code | 29362900 |
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Standard
Authoritative Data Verified Data
This product is N-[4-[(2-amino -5-formyl -1,4,5,6,7, 8-hexahydro-4-oxo-6-pteridinyl) methyl] amino] Benzoyl-L-glutamic acid calcium salt pentahydrate. The C20H21CaN707 content should range from 95.0% to 102.0% based on the water content.
Last Update：2024-01-02 23:10:35
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Trait
Authoritative Data Verified Data
- This product is white to yellowish crystalline or amorphous powder; Odorless.
- This product is dissolved in water, almost insoluble in ethanol or ether; Dissolved in O.lmol/L sodium hydroxide solution.
Last Update：2022-01-01 11:43:56
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take this product, add O. 1 mol/L sodium hydroxide solution is dissolved and made into a solution containing about 10ug per 1 ml, which is determined by ultraviolet-visible spectrophotometry (General 0401) and has a maximum absorption at the wavelength of 282nm, there is minimal absorption at a wavelength of 241NM.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 737) or with that of the control. In case of inconsistency, dissolve the reference sample and the test sample respectively with water (water as little as possible), Dropwise add acetone to produce a sufficient amount of precipitation, place for 15 minutes, centrifuge, and wash the precipitate twice with a small amount of acetone, dry, with the residue to draw infrared light absorption spectrum, should be consistent with the provisions (General 0402).
- identification reaction of calcium salt in aqueous solution of this product (General rule 0301).
Last Update：2022-01-01 11:43:56
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Exam
Authoritative Data Verified Data
pH
take 1.25g of this product, add 50ml of water to dissolve it, and determine it according to law (General rule 0631). The pH value should be 6.8~8.0.
Related substances
take this product, add water to dissolve and make a solution containing about 1 mg per 1 ml, as a test solution; Take appropriate amount of precision, A solution containing 10ug per 1 ml was prepared as a control solution by quantitative dilution with water. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0% ) , the sum of each impurity peak area shall not be greater than 2.5 times (2.5%) of the main peak area of the control solution.
residual solvent
take 0.2g of this product, precision weighing, in the top empty bottle, precision add water 5ml to dissolve, seal, as a test solution; Precision weighing methanol and ethanol appropriate amount, A mixed solution containing about 0.12mg of methanol and 0.4mg of ethanol per 1 ml was prepared by quantitative dilution with water, and 5ml was accurately weighed, placed in a headspace bottle, sealed, and used as a reference solution. According to the test for determination of residual solvents (General rule 0861, Method 1), polyethylene glycol (PEG-20M) was used as stationary liquid, the column temperature was 50°C, and the inlet temperature was 200°C, the detector temperature was 250°C. The Headspace bottle equilibration temperature was 70°C and the equilibration time was 30 minutes. The test solution and the reference solution were sampled by Headspace injection, and the chromatograms were recorded. Calculated by peak area according to external standard method, the content of methanol shall not exceed 0.3%, and the content of ethanol shall not exceed 1.0%.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 16.0%.
Heavy metals
take this product 0.40g, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 50 parts per million.
Last Update：2022-01-01 11:43:57
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel was bonded with OCTA alkyl silane as filler; Disodium hydrogen phosphate buffer solution containing 0.1% tetrabutylammonium hydroxide (10% aqueous solution of 2.2 tetrabutylammonium hydroxide and g of disodium hydrogen phosphate) was dissolved in water to make, the pH value was adjusted to 7.8 with phosphoric acid)-methanol (78:22) as the mobile phase; The column temperature was 40 ° C.; The detection wavelength was 280mn. The number of theoretical plates shall not be less than 2000 as calculated from the folinic acid peak.
assay
take an appropriate amount of this product, weigh it accurately, add water to dissolve and quantitatively dilute it to make it contain about 0 in each lml. 1 mg solution, as the test solution, the precise amount of 10u1 is injected into the liquid chromatograph, the chromatogram is recorded; The calcium folinate reference substance is also taken, the same method is determined, and the peak area is calculated according to the external standard method.
Last Update：2022-01-01 11:43:58
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Category
Authoritative Data Verified Data
antidotes and anti-anemia drugs.
Last Update：2022-01-01 11:43:58
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Storage
Authoritative Data Verified Data
shade, seal, and store in a cool place.
Last Update：2022-01-01 11:43:58
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Calcium Folinate Tablets
Authoritative Data Verified Data
This product contains calcium folinate according to folinic acid (C20H21CaN707) calculation, should be 90.0% ~ 110.0% of the label amount.
trait
This product is white-like to yellow.
identification
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take this product fine powder, add 0.1 mol / L sodium hydroxide solution is dissolved and made into a solution containing about folinic acid lOug per 1 ml, filtered, and the filtrate is taken for determination by UV-Vis spectrophotometry (General rule 0401), there is a maximum absorption at a wavelength of 282nm and a minimum absorption at a wavelength of 241mn.
- take an appropriate amount of fine powder of this product (about 15mg equivalent to folinic acid), add 4ml of water, shake, filter, and the filtrate shows the identification reaction of calcium salt (General rule 0301).
examination
- Related substances take the fine powder of this product, add water to dissolve and make a solution containing about 1 mg of folinic acid per 1 ml, filter, and take the continued filtrate as the test solution; test according to the method under calcium folinate related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0% ) , the sum of each impurity peak area shall not be greater than 2.5 times (2.5%) of the main peak area of the control solution.
- Content uniformity take 1 tablet of this product, put it in a 200ml measuring flask (15mg specification) or a 250ml measuring flask (25mg specification), add an appropriate amount of water, shake to dissolve calcium folinate, dilute to scale with water, shake well, filter, take 10ul of filtrate precisely, measure according to the method under the content determination item, and multiply the result by 0.9256, and meet the requirements (General 0941).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, the solution is filtered, and the filtrate is accurately taken and diluted quantitatively with 0.2mol/L sodium hydroxide solution to prepare a solution containing about folinic acid lOug per 1 ml, the absorbance is measured by UV-Vis spectrophotometry (General rule 0401) at a wavelength of 282nm, calculated as the absorption coefficient of C20H21CaN707 is 575, and the result is multiplied by 0.9256, the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the regulations,
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 20mg equivalent to folinic acid), put it in a 200ml measuring flask, add an appropriate amount of water, shake to dissolve calcium folinate, dilute with water to the scale, shake, filter, take the filtrate as a test solution, according to the method under the determination of calcium folinate content, and the result is multiplied by 0.9256.
category
calcium folinate.
specification
Based on C20H21CaN707 (l)15mg (2)25Mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:43:59
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Calcium folinate injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of calcium folinate. Calcium folinate, calculated as folinic acid (C20H21CaN707), shall be between 90.0% and 110.0% of the labeled amount.
trait
This product is a light yellow to yellow clear liquid.
identification
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take this product and use 0.lmol / L sodium hydroxide solution is diluted to prepare a solution containing about folinic acid lOug per lml, which is determined by ultraviolet-visible spectrophotometry (General rule 0401) and has the maximum absorption at the wavelength of 282nm, there is minimal absorption at a wavelength of 241mn.
- This product is the identification of calcium salt reaction (General 0301).
examination
- the pH value should be 6.5 to 8.5 (General 0631).
- Related substances this product is diluted with water to prepare a solution containing about 1 mg of folinic acid per 1 ml, which is used as a test solution (test according to the method under the item of calcium folinate related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0% ) , the sum of each impurity peak area shall not be greater than 2.5 times (2.5%) of the main peak area of the control solution.
- bacterial endotoxin this product, according to the law to check (General 1143), the amount of endotoxin per 1 mg of folinic acid should be less than 0.36EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take this product and make it quantitatively diluted with water to contain about 0. 1% folinic acid per 1 ml. 1 mg of the solution, as a test solution, was measured according to the method under the item of calcium folinate content measurement, and the result was multiplied by 0.9256.
category
calcium folinate.
specification
calculated by C20H21CaN707 (1) 3ml:30mg (2)5ml:50mg (3) 10ml:0.lg
storage
shading, cold preservation.
Last Update：2022-01-01 11:44:00
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Calcium Folinate Capsules
Authoritative Data Verified Data
This product contains calcium folinate according to folinic acid (C20H21CaN707) calculation, should be 90.0% ~ 110.0% of the label amount.
trait
The content of this product is white to yellow particles or powder.
identification
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take the contents of this product, add 0.1 mol / L sodium hydroxide solution is dissolved and made into a solution containing about 10ug folinic acid per 1 ml, filtered, and the filtrate is taken for determination by UV-Vis spectrophotometry (General rule 0401), there is a maximum absorption at a wavelength of 282nm and a minimum absorption at a wavelength of 241mn.
- take an appropriate amount of the content of this product (about 15mg equivalent to folinic acid), add 4ml of water, shake, filter, filtrate calcium salt identification reaction (General 0301).
examination
- Related Substances: take the contents of this product, add water to dissolve and make a solution containing about 1 mg of folinic acid per 1 ml, filter, and take the continued filtrate as the test solution, test according to the method under calcium folinate related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0% ), the sum of each impurity peak area shall not be greater than 2.5 times (2.5%) of the main peak area of the control solution.
- 1 capsule of this product was added to a 250ml measuring flask, added with appropriate amount of water, shaken to dissolve calcium folinate, diluted with water to the scale, shaken, filtered, the filtrate 10 u1 shall be accurately measured according to the method under the content determination item, and the result shall be multiplied by 0.9256, which shall comply with the regulations (General rule 0941).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, the solution is filtered, and the filtrate is accurately taken and diluted quantitatively with 0.2mol/L sodium hydroxide solution to prepare a solution containing about 10ug folinic acid per 1 ml, measure the absorbance at the wavelength of 282mn by UV-Vis spectrophotometry (General rule 0401), calculate the absorption coefficient of C20H21CaN707 as 575, and multiply the result by 0.9256, the amount of dissolution of each pellet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
take the contents of 20 capsules of this product, precision weighing, mixing evenly, grinding fine, precision weighing an appropriate amount (about 20mg equivalent to folinic acid), put it in a 200ml measuring flask, and add an appropriate amount of water, the calcium folinate is dissolved by shaking, diluted to the scale with water, shaken well, filtered, measured by the method under the item of calcium folinate content determination, and multiplied by 0.9256.
category
calcium folinate.
specification
25mg (calculated as C20H21CaN707)
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:44:01
calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate - Reference Information
| introduction | calcium folinate is an antidote for folic acid antagonistic drugs, also known as calcium folate, calcium folate, calcium aldehyde hydrofolate, ferrous acetic acid, calcium aluronate, calcium formyltetrahydrofolate, yellowish white to yellow crystal or amorphous powder at room temperature, odorless. Easily soluble in water, almost insoluble in ethanol or ether, easily soluble in sodium hydroxide solution. Calcium folinate is a reduced formylated derivative of folic acid. Its effect is similar to that of folic acid. It is an activated form of folic acid in the body. After entering the human body, it is converted into tetrahydrofolate by tetrahydrofolate reductase, which can effectively resist the toxic reaction caused by methotrexate. Calcium folinate has the toxic reaction of "rescuing" excessive folic acid antagonists in the body, which is beneficial to the synthesis of thymine nucleotides, DNA, RNA and even protein, and can stimulate the growth and maturation of white blood cells. This product can limit the damage degree of methotrexate to normal cells, through mutual competition, and can reverse the reaction of methotrexate to bone marrow and gastrointestinal mucosa, but has no effect on the existing neurotoxicity of methotrexate. Mainly used as an antidote for folic acid antagonists (such as methotrexate, methotrexate, phenytoin, phenobarbital, pyrimethamine or trimethoprim, etc.). When oral folic acid is not effective, it is used for stomatitis diarrhea, malnutrition, megaloblastic anemia caused by pregnancy or infancy, and leukopenia. However, it is not applicable to vitamin B12 deficiency anemia. In recent years, calcium folinate has been used as an adjuvant treatment for colon and rectal cancer. Combined with fluorouracil, it can prolong survival. |
| Pharmacological effects | Calcium folinate (CF) is a calcium salt of calcium formyl tetrahydrofolate derivative, which is an activated form of folic acid in the body. It is mainly used as an antidote for folic acid antagonistic drugs, such as aminopterin, methotrexate, pyrimethamine and trimethoprim, which can competitively inhibit dihydrofolate reductase and prevent folic acid from becoming tetrahydrofolic acid, leading to DNA synthesis disorders, and supplementing calcium formyltetrahydrofolate can detoxify. It can also treat megaloblastic anemia caused by folic acid deficiency, and promote the differentiation, maturation and release of bone marrow hematopoietic cells. In recent years, a large number of experiments and clinical studies at home and abroad have fully proved that calcium folinate can be used as an efficient biochemical regulator, which can significantly enhance the anti-tumor activity of fluorouracil (5-FU) drugs. Fluorouracil is a pyrimidine antagonist, which is the main drug for the treatment of gastrointestinal tumors, breast cancer, head and neck cancer and trophoblastic tumors. Calcium folinate is easy to be absorbed orally, and the serum folate reduction can reach the peak value at (1.72±0.80) hours; It is (0.71±0.09) hours when injected intramuscularly. The half-life of serum folate reduction after intramuscular injection is 3.5 hours. The drug effect was maintained for 3 to 6 hours. The metabolite is 5-methyltetrahydrofolate, which is excreted through the kidney 80% ~ 90%. |
| usage | is used to treat megaloblastic anemia, 15mg orally every day; Or intramuscular injection of 1~5mg per day, and oral administration of 5mg/d after 10~15 days until blood picture is normal and symptoms disappear. If the deficiency of cobalamin cannot be ruled out, it should be combined with cobalamin adenosine. It is used for rescue of methotrexate, 3-4 times a day, 5-15mg orally for 2 days; Or 3-6mg intramuscular injection; Methotrexate is ineffective after taking this drug for more than 4 hours. Used for detoxification of pyrimethamine or trimethoprim, 5~15mg orally daily. Calcium folinate is used in combination with fluorouracil, 20~30mg/m2, and is taken orally half an hour after fluorouracil administration. |
| drug and application | calcium folinate (CF) has no anti-tumor effect by itself, and is mainly used for high-dose rescue and simultaneous application with fluorouracil to strengthen the therapeutic effect of the latter. The so-called high-dose methotrexate-calcium folinate (HD MTX-CF) rescue therapy is the application of MTX intravenous drip more than 100 times higher than the conventional dose, generally 2~5mg/m2, intravenous drip for 4~6h, so that the blood concentration reaches a fairly high level, so that the intracellular MTX reaches an effective concentration above 10-5mol/L. In this way, it can be spread to solid tumors with poor blood supply and cross the physiological barriers such as blood-cerebrospinal fluid and testis. However, high-dose MTX can have fatal toxic reactions, so detoxification measures must be taken within a certain time after MTX drip. CF rescue usually starts 2~18 hours after MTX drip ends. Intramuscular injection or intravenous injection at a dose of 6~15 μg/m2, once/6h, for a total of 12 times for 3 days. CF dose and injection time are related to the application of MTX, that is, the blood drug concentration of MTX can be stopped when the safety threshold is below 10-7mol/L. In addition, auxiliary hydration and alkalization treatment should be given to support it. The preparation of CF is generally 6mg water injection. Another therapy is calcium folinate and fluorouracil to improve the efficacy of the latter, which is generally called CF-FU combination therapy. The principle is: in the process of DNA synthesis, deoxyuridonic acid (dUMP) needs to accept the methyl group converted from tetrahydrofolate (THF) under the catalysis of adenylate synthase (TMPS) to form deoxyadenylate (d TMP). At this time, dihydrofolate reductase converts dihydrofolate into tetrahydrofolate. The main mechanism of action of fluorouracil is to become fluorouracil deoxynucleotide after entering the human body, inhibiting TMPS. During the reaction, TMPS, THF, and dUMP 3 form a transitional complex. After the general reaction is over, this complex decomposes and releases dihydrofolate, TMPS and dTMP. However, after FU is given, this complex cannot be decomposed, the function of the enzyme is inhibited, and dTMP cannot be generated. The binding force of the fluorouracil deoxynucleotide to the enzyme is proportional to the concentration of THF. Increasing the supply of THF can enhance the effect of FU in inhibiting TMPS. The specific clinical application is generally: intravenous drip of 200~500mg/m2CF for 2 hours first, intravenous injection of FU370mg/m2 after drip, and continuous use for 5 days as a course of treatment; This treatment can be repeated for 21~28 days. This CF-FU combination therapy has a better effect on the treatment of colorectal cancer, which is better than FU alone, and the adverse reactions have not increased much. |
| adverse reactions, contraindications and drug effects | occasional rash, urticaria or asthma, etc. Malignant anemia or megaloblastic anemia caused by vitamin B12 deficiency is contraindicated. It is not suitable to be used at the same time as folic acid antagonists such as methotrexate, and this drug should be applied 24~48h after using large doses of methotrexate; be careful to combine acidic urine, ascites, water loss, gastrointestinal obstruction, pleural effusion or The detoxification treatment of methotrexate for renal dysfunction; for those in urgent need of the disease, the dosage of this drug should be increased; creatinine clearance rate should be measured before treatment, and plasma or serum methotrexate concentration should be measured every 12~24 hours after the application; serum creatinine was measured before and every 24 h after treatment with methotrexate, and the 50% after treatment was greater than that before treatment, indicating severe nephrotoxicity. Urine acidity was monitored every 6h before and after methotrexate, urine pH value was kept above 7, and sodium bicarbonate and hydration were used if necessary. A larger dose is used together with barbiturate, promione or phenytoin sodium, which can affect the antiepileptic effect. |
| use | 1. Mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.). 2. It is used to prevent severe toxic effects caused by excessive or high-dose methotrexate treatment. 3. Megaloblastic anemia caused by folic acid deficiency. 4. When combined with fluorouracil, it is used to treat advanced colon cancer and rectal cancer. It can be used to relieve the toxic reaction caused by the overdose of aminotrexate and methotrexate, and it can also be used to treat giant red blood cell anemia. Calcium folinate counteracts the effect of folic acid antagonists, which bind folic acid dehydroreductase (dihydrofolate reductase) to prevent the conversion of folic acid into tetrahydrofolic acid. Medically, after methotrexate chemotherapy, calcium folinate is used to reduce the toxicity of methotrexate. Calcium folinate also enhances the cytotoxic effect of 5-fluorouracil in anti-cancer. Calcium folinate can counteract the effect of folic acid antagonists. Folic acid works by binding dihydrofolate reductase and blocking the conversion of folic acid into tetrahydrofolate. In medicine, calcium folinate is used to reduce the toxicity of methotrexate after methotrexate treatment. |
Last Update：2024-04-09 19:05:10
![calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate](http://res.chembk.com/assets/str/2d/1/14/1492-18-8.png)
Supplier List
Product Name: Calcium folinatc Request for quotation
CAS: 1492-18-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 1492-18-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Folinic Acid Calcium Salt Visit Supplier Webpage Request for quotationCAS: 1492-18-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Calcium folinatc Request for quotation
CAS: 1492-18-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 1492-18-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Folinic Acid Calcium Salt Visit Supplier Webpage Request for quotationCAS: 1492-18-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History